Has CBD ever worked for anyone?

Medical
#11

@SlingShot the thing about cbd is that it degrades much faster than thc so anything store bought check the date. If it isn’t within 30 days of the manufacturing date it isn’t close to as potent as what it says on the label and they are often mislabeled to begin with. Most studies show that the estimated dosage in many of the consumer cbd products is grossly overestimated and nowhere near the amounts claimed. So don’t discount cbd because you bought a bad batch from the store. The FDA is working on creating stricter regulations so people aren’t being mislead by companies trying to take advantage of people looking for therapeutic relief.

Another thing to look at is how people metabolize cbd and the delivery method. Smoking cbd is more effective as more cbd stays viable vs eating it but the effects don’t last as long. Edibles on the other hand have longer lasting effects but they need to be made with a higher amount or cbd to account for the 30%+ that is lost in the stomach and during first pass liver metabolism. This can be reduced by using sunflower lecithin in making home made cbd oils as sunflower lecithin increases bioavailability of cannabinoids by protecting them and keeping more viable for first pass liver metabolism and also by aiding the liver in processing the cannabinoids so less are wasted by the body.

Another big thing to take into account is the health of your liver. If your liver has trouble processing fats or other things or if you have liver damage it can effect the way you metabolize cbd and cbd can potentially cause more liver damage in high doses if your liver is already unhealthy or if excessive amounts are taken.

With all this being said cbd can be an extremely effective medicine for combating neuropathic pain. Your best bet is to make home made tinctures or edibles so the cbd is “fresh” and more bioavailable cannabinoids remain.

Based on what you said about your injuries though it sounds like you have combination nociceptive and neuropathic pain. Cbd will help with the neuropathic pain and inflammation but the nociceptive pain will require some thc as well. The proper terpene profile will also make a huge difference.

I’d personally do a 1-1 or a 2-1 thc-cbd ratio to treat your nociceptive and neuropathic pain from injuries. I’d also look into cultivars high in caryophylene, myrcene, linalool, and other pain/inflammation busting terpenes that work with thc and cbd.

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#12

I personally think it just has a placebo effect, if any. JMHO, yours may vary.

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#13

@everyone I forgot to mention that thc tolerance directly effects the efficacy of cbd treatment.

CBD binds with CB1 receptors just like THC but more gently and doesn’t cause them to down regulate. THC on the other hand has a stronger bond and will cause CB1 receptors to down regulate.

Down regulating pretty much means they shrink away or hide when over stimulated. Over stimulation of CB1 receptors can occur when THC is used frequently in high volumes.

With this all said we all should know by now that the more healthy active receptors we have the more effective a medicine will be.

Often times in order for CBD to be effective we need to cut back on THC for a bit so that CB1 receptors can heal and stop down regulating so that the CBD has more receptors to bind to and interact with.

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#14

I did not know that they used the same receptors in the brain. I thought they had different receptors, thc and cbd. That is good to know, especially with dosing. Specifically for someone fighting a medical condition and not just feeling irie.

MDbuds, would you suggest someone focusing on the cbd for a treatment down the thc levels then.? Like thc every other day rather than a daily blend with the cbd? I give my extracts to a lot of sick people so I find this very relevant. I do a few high cbd strains for a neighbor that had masses surgically removed from her brain stem. And a few other cancer patients. Anyway, I usually do a 1:1 blend at extraction with same mass of whole raw plant. Would I be better to not blend them so I can have a all cbd oil too? It would be easy to do.

I wonder if thc saturation is why so many felt cbd was not helpful for them dosed alone.? My mind is racing now…

Hey, the raw plant at the end to get thca, cbda, and the terp burp boost has been working great. Thanks for the tips there MDbuds.

Totally off topic (more a story) but I also have a client (patient?) with terrible type2 diabetes. He first started using my extract for neck and back pain (retired old school pipe fitter). He is in his late 60s. Anyway, he found it is a miracle for his lower leg neuropathy. He has to walk with 2 canes very carefully. 1 hour after canaoil he can walk without his canes and feel his feet. He had been tied to his canes for about 10years before the canaoil.

Also, my lil sis got type 1 diabetes at age 3. Insulin shots twice a day her whole life. We noticed her blood sugar would have less peaks and valleys and stay in a narrow range when older she started using cannabis. With the modern insulin pumps computer tracking blood sugar to the minute, this trend continues. She uses about half the volume of insulin in her body when she also uses cannabis regularly. I guess what I am saying with these 2 stories is: I bet cannabis helps more with blood sugar regulation than any one officially treating these ailments knows. I was just surprised how much it helped people in my life. The pipe fitter was anti cannabis before I installed his fish tank. He used to just pop opiate pills like candy. He says now no more pills unless he runs out of oil. Sorry for the off topic ramble.

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#15

@Noddykitty I would suggest taking a thc “tolerance break” when medicine starts becoming ineffective.

Dosing with a 1-1 is great or even alternating as you suggested but sometimes you will need to reset your ecs so both cbd and thc can become more effective again. Just cut out thc for a few days to a few weeks but you can still dose with cbd because it doesn’t cause CB1 receptors to down regulate.

THC, THCV, CBD, limonene, and myrcene have actually all been looked into as a potential therapeutic treatment for diabetes. I don’t recall the exact methods but I have my literature somewhere. I do recall though that myrcene specifically increases the body’s insulin sensitivity allowing sugars to be metabolized which is why it’s a potential treatment for diabetes. It’s also why high myrcene strains make you so damn hungry.

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#16

@Noddykitty here’s my rundown about CBD and thc tolerance from another topic.

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#17

Before my father-in-law passed 3 years ago, he was diagnosed with cancer (pancreatic? can’t remember!). He was like 91, old-school Scot who loved his scotch but I could never admit to the family that I was a cannabis enthusiast. Doctors just kept giving him opiates for pain. He eventually asked what I thought about marijuana for pain relieve as it was now legal in Canada for recreation and was splashed all over the news. “Well, yeah I have friends…”.
Managed to get a gram of CDB 99% pure crystals from one of them, put about a peppercorn’s worth under the tongue in the morning, helped with his pain and appetite. Went with him on his next visit (he couldn’t drive, barely walk, but was still a stubborn old fart!) and the doc was talking pain management. More opiates which were messy with his appetite. I outright asked him what he thought of cannabis. Ended up with a prescription for some of the Tilray 10-10 drops (10mg THC and 10mg CBD).
Using their dosages, it helped a bit. Got him to double it, and that really helped with his pain and appetite. And mood! He hated the taste of his “Hippy juice” as he called it, but I believe he really felt the effects and the benefits.
I did come clean and told him I’d been using for 40 years before he passed about 5 months later. And yes, I made sure I got the near empty bottle and the full one that just arrived for my back pain!

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#18

I view CBD as a multi vitamin. It’s best to have it build up in your system. It takes time to get your endo cannabinoid system in balance.

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#19

cbd is good for stress. which was the reason I smoked it back in the late 80s, smoked everyday from sun up too sun down, quit for 17 yrs. & now it’s legal & able to grow my own

#20

@SlingShot Hey Sling, you know I gotta put in my 2 cents. Last year I grew some Blue Dream Auto from another seed provider claiming 2%CBD and 20% THC. Since starting each day with that as my "wake and bake ",I have discontinued the 1-4 Alleve I had been taking since my back surgery in2010.

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#21

Sounds like you found something that works for you.

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#22

@SlingShot Yeah, I don’t know if it is the CBD or THC or the entourage effect of all the trichomes, but it is still working well for me. :stuck_out_tongue_closed_eyes:

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#23

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#24

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#25

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#26

I use muscle recovery CBD gummies for pain during the day and THC gummies at night. The recovery gummies (orange flavor!) have CBG also. I have severe lower back pain from an accident 25+ years ago. Sitting is my most comfortable position but when I sit for long periods I start feeling pain. I consistently take two recovery gummies every day. With CBD it’s important to build up in your system for optimum benefits. It helps with my inflammation and gives me relief. At night, I take one THC gummy every night and it helps me relax and sleep. Without it my pain is very bothersome and I toss and turn all night. I wake up feeling refreshed and ready for another day!

#27

CBD is an excellent antidote and moderator for THC.

If you are inexperienced and get too much THC, a dose of CBD will bring you back to grips.

Conversely, if you take a bunch of CBD, good luck getting high for the next 2 days.

It is good to have a little CBD in your THC, but only a little.

#28

Yes. Honestly, when it comes to using cannabis you need to try every method more than once. Every body will respond differently.
Generally speaking, CBD for pain, THC for anxiety/stress (chill out )!

#29

I think a lot of it comes down to the individual. Some of my friends swear by CBD for easing joint pain or anxiety, while for me it never seemed as strong as even a small amount of THC. I do find a balanced 1:1 tincture helps me relax in the evening, especially when paired with a hot bath.

My partner uses CBD oil before bed and says it helps her wind down. We also like trying new products together. One of the things I enjoy is the way our local shop packages their products. Brandmydispo makes these cool custom jars and labels that make the whole experience feel special. Even if the CBD effects are subtle, opening a nicely packaged jar adds to the ritual.

At the end of the day, everyone reacts differently. It might take a bit of experimenting with different strains, ratios and delivery methods to see if it works for you.

#30

From what I’ve seen, CBD seems to be hit or miss. Some people swear by it for sleep or anxiety, but when it comes to actual pain relief it usually isn’t very strong. I tried it a few times myself and didn’t notice much difference, especially with joint pain. The only time people I know said it really helped was when it was paired with THC, otherwise the effect was pretty mild.

I think it really depends on the person and the type of issue they’re trying to treat. For chronic injuries or serious pain, most folks don’t seem to get much out of CBD alone.